Download 2008 Amendments to the National Academies' Guidelines for by National Research Council, Institute of Medicine, Board on PDF

By National Research Council, Institute of Medicine, Board on Health Sciences Policy, Division on Earth and Life Studies, Board on Life Sciences, Human Embryonic Stem Cell Research Advisory Committee

In 2005, the nationwide Academies published the record instructions for Human Embryonic Stem cellphone learn, which provided a standard set of moral criteria for a box that, end result of the absence of entire federal investment, used to be missing nationwide criteria for research.

In order to maintain the information modern, given the quick speed of clinical advancements within the box of stem mobilephone examine, the Human Embryonic Stem telephone examine Advisory Committee used to be tested in 2006 with aid from The Ellison scientific starting place, The Greenwall beginning, and the Howard Hughes scientific Institute.

As it did in 2007, the Committee pointed out matters that warranted revision, and this publication addresses these matters in a moment set of amendments. most significantly, this booklet addresses new medical advancements in reprogramming of somatic cells to pluripotency by means of including a brand new part and revising different proper sections of the Guidelines.

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Extra resources for 2008 Amendments to the National Academies' Guidelines for Human Embryonic Stem Cell Research

Sample text

Particular attention should be paid to at least three factors: the extent to which the 35 36 Appendix A implanted cells colonize and integrate into the animal tissue; the degree of differentiation of the implanted cells; and the possible effects of the implanted cells on the function of the animal tissue. 3(c)]: (1) E  xperiments that involve transplantation of hPS cells into human blastocysts. (2) Research in which hPS cells are introduced into nonhuman primate embryos, pending further research that will clarify the potential of such introduced cells to contribute to neural tissue or to the germ line.

E) Clear criteria for distribution of cell lines, including but not limited to evidence of approval of the research by an embryonic stem cell research oversight committee or equivalent body at the recipient institution. 0 RESEARCH USE OF hES CELL LINES Once hES cell lines have been derived, investigators and institutions, through ESCRO committees and other relevant committees (such as an IACUC, an IBC, or a radiation safety committee) should monitor their use in research. 1 Institutions should require documentation of the provenance of all hES cell lines, whether the cells were imported into the institution or generated locally.

Iii) Research in which the identity of the donors of blastocysts, gametes, or somatic cells from which the hES cells were derived is readily ascertainable or might become known to the investigator. 3(c) hES cell research that should not be permitted at this time The following types of research should not be conducted at this time: (i) Research involving in vitro culture of any intact human embryo, regardless of derivation method, for longer than 14 days or until formation of the primitive streak begins, whichever occurs first.

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